L-Hydroxyproline is a nonessential amino acid derivative

L-Hydroxyproline is a nonessential amino acid derivative formed during post-translational protein modification through hydroxylation of the amino acid proline by the enzyme prolyl hydroxylase which requires vitamin C as a co-factor. Hydroxyproline is a major component of the protein collagen and plays a key role in the stability of the collagen triple helix. It can be used as an indicator to determine the amount of collagen. Increased hydroxyproline levels in the urine and/or serum are normally associated with degradation of connective tissue. Vitamin C deficiency decreases the conversion of proline to hydroxyproline, which leads to reduced collagen stability.L-Ornithine is an amino acid that plays an important role in the urea cycle. It plays an important role in the discharge of ammonia nitrogen in the body. It has different names and forms such as L-ornithine and aspartate ornithine (OA).